For men with itchy urethra, it is recommended to take macrolides as the best anti-inflammatory drugs, mainly erythromycin, roxithromycin, clarithromycin, minocycline, doxycycline, and azithromycin. These drugs can effectively kill mycoplasma and chlamydia. Cephalosporins and quinolones are not effective against mycoplasma and chlamydia. For male urethra itch, it is mainly caused by non-gonorrhea infection, for this condition, a discharge test should be done to effectively confirm the diagnosis. For this situation, the couple should be treated at the same time to prevent cross-infection between the couple due to sexual intercourse, resulting in a long period of time without healing.