Men with itchy and painful urethra, it is recommended to go to the hospital to check the cause and give symptomatic drug treatment after diagnosis: 1, non-gonococcal urethritis, it is a sexually transmitted disease, you need to take oral doxycycline (enteric) capsule one, 2 times / day, two weeks of continuous oral; or intravenous Azithromycin injection 500mg, 1 time / day, 10 days of continuous use for treatment, during the treatment period, abstain from sexual intercourse. 2, gonorrhea, also belongs to a kind of sexually transmitted, can appear itchy and painful in the urethra with increased discharge, it is recommended to inject ceftriaxone sodium 1.0g intravenously, 2 times/day for one week. 3, non-specific urethritis, can appear corresponding symptoms, it is recommended to take cefixime capsule orally, one capsule, 2 times/day for 10 days; or levofloxacin hydrochloride capsule, one capsule, 3 times/day for 10 days. For 10 days, observe whether there is any improvement in symptoms.