Dryness syndrome is characterized by dryness of the hands and feet, as well as other local symptoms such as dry mouth and eyes, and involvement of the digestive, respiratory, renal and other systems or organs. Dry syndrome mainly involves exocrine glands, such as sweat glands, and therefore dry skin is present, including dry skin on the hands and feet. The disease also presents with localized symptoms such as dry mouth, dry eyes, dry nose, Raynaud’s phenomenon, joint pain, vaginal dryness in females, recurrent parotid enlargement in adulthood, and rampant dental caries. Dry syndrome mainly involves the respiratory system, digestive system, kidneys, nervous system and blood system. If the digestive system is involved, gastroesophageal reflux and liver function impairment will occur; the respiratory system is mainly involved in interstitial lung disease, manifested as dry cough and wheezing; renal lesions are mainly based on renal tubular interstitial lesions, manifested as polydipsia and nephrogenic urolithiasis. If dry syndrome dry hands and feet phenomenon, you need to go to the hospital rheumatology and immunology department in a timely manner, under the guidance of the doctor to improve the relevant examination to clarify the diagnosis, targeted treatment.