If you take one tablet of eszopiclone and it doesn’t work, it may be due to insufficient dosage, expiration of the drug, drug resistance and other reasons. 1. Insufficient dosage: Estazolam comes in different dosage forms and specifications, and the dosage varies depending on the patient’s condition. If the patient takes an insufficient dosage of the drug, for example, two tablets are required, but only one tablet is taken, there may be no obvious effect. 2. Drug expiration: the drug will only be effective if taken within the expiration date, if the expiration date is over, it may lead to drug ineffectiveness; it may also be due to improper storage of the drug and lead to drug failure. 3. Drug resistance: some patients are prone to drug resistance due to long-term use of the drug, so there may be no significant effect when taking the product. Eszopiclone must be taken correctly under the guidance of a professional doctor, not to take the drug at will, and should pay attention to the production date and expiration date of the drug.