If coughing with phlegm blockage leads to wheezing, first aid is needed by suction followed by oxygen, etc. If the patient has tracheal or bronchial stenosis, surgical first aid is needed. If the cough is caused by bronchial asthma or chronic obstructive pulmonary disease, it is recommended to take emergency medicine. 1. Sputum blockage: Coughing is caused by sputum blockage can not breathe need to use sputum suction to suck out the sputum in a timely manner, with the mask oxygen or nasal catheter oxygen. In addition, patients can also follow the doctor’s instructions with budesonide suspension, ipratropium bromide and other drugs for nebulization therapy. 2. Tracheal or bronchial stenosis: Tracheal or bronchial stenosis that causes coughing and wheezing requires surgical resection of the stenosis, bronchoscopic stenting. Combined respiratory support, such as non-invasive ventilator-assisted ventilation, emergency tracheal intubation or tracheotomy if necessary. 3. Bronchial asthma: If bronchial asthma leads to breathlessness, you can give the patient inhalation of short-acting β2 agonists under the guidance of the doctor, such as salbutamol aerosol, terbutaline sulfate aerosol, etc., and glucocorticosteroids can be given intravenously if necessary. 4. Chronic obstructive pulmonary disease (COPD): In acute exacerbation of COPD, it is necessary to apply anti-infective drugs such as amoxicillin, levofloxacin and other antibiotics. Combined bronchodilators such as inhaled formoterol, salmeterol and other long-acting β2-adrenoceptor agonists, M2 receptor antagonists such as ipratropium bromide, with aminophylline and so on. It is recommended that patients with coughing and wheezing need to consult a doctor in a timely manner, the doctor will choose targeted measures for the treatment of the patient’s condition.