Ornidazole-induced neurologic derangement should be promptly discontinued and treated with supportive, symptomatic therapy. If an adverse reaction occurs with the use of ornidazole, the infusion or administration should be stopped immediately. Neurologic confusion is a more serious adverse reaction and should be seen as soon as possible to ensure an open airway and oxygenation. Sedatives such as diazepam can be used symptomatically if there are symptoms such as over-excitement and mania. Neurologic confusion after taking ornidazole is an extremely rare adverse reaction, and common adverse reactions to ornidazole include gastrointestinal reactions and dizziness. Attention should be paid to differential diagnosis, whether it is caused by other encephalopathies, schizophrenia, and should be treated for the cause after detailed examination. If the insanity is caused by ornidazole usually improves after stopping the drug. In case of neurological disorders after taking Ornidazole, it is recommended to consult a doctor in time for treatment and medication under the doctor’s guidance.