The treatment program of microscopic lesion nephropathy mainly consists of general treatment, symptomatic treatment, immunosuppressive treatment, and complication prevention and treatment.
1. General treatment: pay attention to rest, avoid public places and prevent infection. Low-salt, low-fat, high-quality and low-protein diet.
2. Symptomatic treatment: diuretics such as furosemide, hydrochlorothiazide, etc. can be applied to reduce swelling; application of lACEI or ARB drugs, such as captopril, irbesartan, etc. to lower blood pressure and reduce urinary protein.
3. Immunosuppressants:
(1) Glucocorticoid: by inhibiting immune inflammatory reaction, inhibiting aldosterone and antidiuretic hormone secretion, affecting the glomerular basement membrane permeability and other comprehensive effects to play its diuretic, eliminating urinary protein efficacy. 90% of patients with microscopic lesion nephropathy are sensitive to glucocorticoid therapy, and can be treated with prednisone or methylprednisolone.
(2) Cytotoxic drugs: such as cyclophosphamide, these drugs can be used in “hormone-dependent” or “hormone-resistant” patients, synergistic hormone therapy.
(3) Calcium-modulated phosphatase inhibitors: such as cyclosporine and tacrolimus, which can be used to treat nephrotic syndrome in which hormones and cytotoxic drugs are ineffective.
(4) MORTIMERS: MORTIMERS is recommended for patients who cannot tolerate glucocorticoids, cyclophosphamide, and calcium-modulated phosphatase inhibitors.
4. Complications prevention and treatment: prevention of infection, thrombosis and embolic complications, acute kidney injury, protein and fat metabolism disorders.
Patients with microscopic lesion nephropathy are advised to go to regular hospitals in time and receive standardized treatment under the guidance of doctors. The above drugs should be used according to the doctor’s prescription.