Plague is a virulent infectious disease transmitted mainly by the plague bacillus through rodent fleas, also known as the Black Death, a natural epidemic disease prevalent among wild rodents. The clinical manifestations include fever, severe toxemia, enlarged lymph nodes, pneumonia, and hemorrhagic tendencies. The plague has had several pandemics in the history of the world, with tens of millions of dead. The outbreak of plague in the northeast in 1910-1911 was recorded to have killed 60,000 people, but some scholars have estimated that the number of deaths should be ten times or even a hundred times. The Himalayan dry otter is a key surveillance target for plague prevention in the Asian region, and is also the source of many plague outbreaks in Qinghai, Gansu, and Tibet (Sichuan-Tibet) in China. The deceased from the plague in Yumen, Gansu, found a dead dry otter on July 13 and then chopped it up and fed it to dogs. The deceased developed a fever that night, which was relieved after taking antipyretic drugs since, but the condition suddenly worsened on the 15th and was sent to the hospital for resuscitation on the 16th and died that night! There are several ways to spread plague: rodent → rat flea → human transmission is the main way to spread glandular plague. It can be spread by respiratory droplets and can cause a pandemic of plague in humans. Infection can occur through skin wounds by eating the skin or flesh of diseased rodents or by direct contact with the pus, blood or sputum of patients. People can get infected by eating undercooked infected meat. Clinical symptoms are: 1. Light type: Initially there is irregular low fever, mild systemic symptoms, local lymph node swelling and pain, occasionally pus, no bleeding phenomenon. 2, glandular type: the most seen acute chills, high fever, headache, fatigue, generalized aches and pains occasionally nausea, vomiting, restlessness, skin bruises, bleeding. Swollen and painful lymph nodes in the drainage area of the flea bite can be seen at the onset of the disease, and develop rapidly, with the inguinal lymph nodes most often involved, followed by the axilla, neck and submandibular. Due to the intense inflammation of the lymph nodes and surrounding tissues, they are in a forced position. If left untreated, the enlarged lymph nodes rapidly become septic, break down, and die within 3 to 5 days due to severe toxemia, secondary pneumonia, or sepsis. If the treatment is timely or mild, the adenoma gradually dissipates or the wound heals and recovers. 3. Pulmonary type: It can be primary or secondary to the glandular type. Pulmonary plague develops rapidly, with acute onset of high fever and obvious symptoms of systemic toxicity. Respiratory distress and cyanosis rapidly increase. The lungs can be smelled as a wet stall bow stop escape from the breakfast (19) to break into 2 front mute beer N Chun 笆Nose calcium day chattering death from heart failure and shock within 2 to 3 days. The skin is often blackish-purple before dying, so it is called the black death. Prognosis: There is no effective vaccine for plague. The prognosis for pulmonary and septicemic plague is extremely poor if not rescued in time. The younger or older the person is, the worse the prognosis is. The key is early diagnosis and timely treatment. Strict isolation is especially important due to respiratory transmission between humans. The principle of pathogen-specific treatment is early, combined, and adequate application of sensitive antibiotics. Once in the middle and late stages, the treatment effect is extremely poor. Previously Gansu Chuanbei highway traffic police issued a micro-blog to prevent the spread and dissemination of the plague epidemic, even Huo highway Chikin toll station temporarily closed. Pay close attention to the development of this plague in Yumen, Gansu, and isolate and observe the people in contact, I hope there will not be a second case!