Esophageal pain in the middle of the night is usually caused by reflux esophagitis, esophageal cancer, etc. The treatment plan should be chosen according to the specific situation, which can be treated by medication, improved diet and surgery. The medication should follow the doctor’s prescription. 1. Medication: For the esophageal pain in the middle of the night caused by reflux esophagitis, drugs that inhibit the secretion of gastric acid and promote gastrointestinal dynamics can be used to relieve the pain, such as omeprazole, rabeprazole, mosapride and cisapride. 2. Improve diet: patients with esophageal pain in the middle of the night due to reflux esophagitis can effectively promote gastrointestinal peristalsis and digestion by consuming foods containing crude fiber, which can effectively relieve esophageal pain. 3. Surgery: For esophageal cancer, esophagitis and other organic lesions causing esophageal pain in the middle of the night, it is necessary to go to regular hospitals in time to receive esophagogastroscopy, to clarify the cause of the disease, and then follow the doctor’s instructions to use surgical resection to relieve the pain. It is recommended that patients with esophageal pain in the middle of the night should pay attention to their diet in their daily life and try not to consume stimulating foods to prevent aggravation of the condition. In addition, it is recommended that patients seek timely medical attention to clarify the cause of the disease and then carry out appropriate treatment under the guidance of the doctor.