Chronic hepatitis B can be cured. The treatment of chronic hepatitis B is mainly antiviral therapy, through which the viral load can be reduced, such as the application of interferon, entecavir, tenofovir, etc. After viral load reduction, serologic conversion should also be achieved, and finally negative surface antigen conversion should be pursued to achieve clinical cure. During the treatment process, patients should work closely with their physicians and pay attention to diet, rest, and emotional factors. The current goal of treatment for chronic hepatitis B is to pursue clinical cure and reduce the occurrence of hepatocellular carcinoma as much as possible.