Sotossyndrome, or cerebralgigantism, cerebralgigantismsyndromeinchildhood, also known as childhood giant brain syndrome ( macrencephalysyndrome, Sotos syndrome, is a syndrome in which the skeletal development grows too fast, the head is huge, and the intellectual development is delayed in infants and school-age children. The cause of this syndrome is unknown. It may be caused by pathological factors in utero or by impairment of the hypothalamic-pituitary axis. It is thought to be familial and dominantly inherited, with a higher incidence in males than in females (4:1 or 3:1), so it is usually considered to be an X-linked disorder. The birth weight and length of the child are greater than normal, and the growth is rapid for 4-5 years after birth, then the growth seems to approach normal and stable, however, the measured value is still more than two standard deviations from the mean for the same age. The child may have a giant skull, long head, distant eye spacing, congenital dullness, peculiar facial features, prominent jaw, high palatal arch, mental retardation, clumsy movements or ataxia. Sometimes there may be obesity, twitching, abnormal hand skin pattern (increased number of total finger ridges between triangle a-b, large interfoveal pattern and fingerprints with bucket-shaped pattern), but there are also reports of abnormal skin texture. The disease is treated symptomatically and should be observed with long-term follow-up. In the neonatal period, jaundice is often delayed and requires active treatment such as phototherapy and comprehensive systemic examination; in infancy, recurrent respiratory infections, epilepsy and malignant tumors are common, and the incidence of tumors is significantly higher than that of healthy people, especially with increasing age. Therefore, we should be highly vigilant and adhere to the follow-up; to around puberty because of the huge brain can have a vertical growth of facial length, affecting the development of teeth and other orthodontic treatment is required. Rehabilitation and special education should be designed and implemented for the child and continue throughout the life of the intervention. The final height of the child is unpredictable, but normalizes with age, with most abnormal growth ceasing around puberty. The prognosis for this condition is generally healthy beyond childhood.