In recent years, the incidence of thyroid cancer has increased dramatically, especially papillary cancer, which has doubled from a decade ago. Many patients with papillary thyroid cancer have gone through a period of psychological adjustment from being bewildered and confused when they first learned about the disease to gradually facing it openly. Through communication with doctors and independent study of papillary thyroid cancer, many patients have become more and more aware of this disease. However, in the daily outpatient work, there are still some patients who cannot cooperate well with the doctors in the post-surgery follow-up work. On the one hand, this causes inconvenience to the doctor’s treatment, and on the other hand, it also affects the effectiveness of the patient’s follow-up treatment. So, what can be done to make patients with papillary thyroid cancer manage their disease well and cooperate with doctors for good follow-up work? Firstly, they should keep the meaningful data during their surgical hospitalization. These include: discharge records, pathology results, surgical methods, etc. This is very important for the doctor to review the patient’s medical history comprehensively and quickly. Second, medications should be taken in strict accordance with the doctor’s orders and on time. Some patients feel that taking medication will cause dependence, so they take the initiative to stop taking medication or change the dosage of medication by themselves. For papillary thyroid cancer, although the prognosis is relatively good, there is also a requirement for strict drug control of hormone levels after surgery. Please do not replace the standardized treatment by doctors with non-professional personal understanding. Of course, it is not necessary to be too nervous to break the medication for one or two days occasionally due to some special reasons. The half-life of thyroid hormones in the body is long, so once or twice occasionally will not cause great impact. Thirdly, you should review your thyroid hormones strictly and regularly, and keep the report of each examination and the corresponding medication dosage properly, especially within one year after surgery. If the results of the postoperative review are unsatisfactory, the doctor will ask to review the corresponding indexes every month. Some patients feel that they have been free of discomfort after repeated follow-up for several months, so they think that the doctor is making a big deal out of it and extend the interval of review on their own. Fourth, some patients need to undergo internal irradiation iodine 131 radiotherapy treatment after surgery, so they should keep their radiotherapy plan and related information properly. Postoperative management of papillary thyroid cancer patients is a lifelong task that needs to be maintained by both doctors and patients. Although the percentage of patients who die from papillary thyroid cancer is very small, there are still some patients who will have a high degree of malignancy. Therefore, every patient should treat it seriously and pay attention to it under the guidance of doctors.