Acute herpes zoster, commonly known as “herpes zoster” and “herpes zoster”, is a disease characterized by severe pain that occurs in the elderly and those with reduced immunity. Herpes is characterized by severe pain, usually in the elderly and people with reduced immunity. Patients are highly sensitive to pain and the pain level is abnormally intense, and it is called the “king of pain” along with trigeminal neuralgia. The duration of postherpetic neuralgia can be as short as 1 to 2 years or as long as 10 years. There is no method to completely and simply eliminate herpes zoster neuralgia. After several years of research and practice, we have concluded a set of sequential comprehensive analgesic measures, which can significantly relieve the pain of about 90% of patients with postherpetic neuralgia through 1-3 months of continuous treatment, and finally reach a situation where daily life can be tolerated, significantly improving the quality of life of patients. The core of our set of sequential comprehensive analgesic measures is to actively adjust certain local drug regimens and doses of the comprehensive measures according to the patient’s response to treatment, and to use neuromodulation and neurodestructive treatments when appropriate. The specific protocol includes several aspects: 1. Systemic adequate dosing including early onset antiviral drugs and neurotrophic drugs. The primary drugs are neurofilm stabilizing doses, anti-inflammatory and analgesic drugs and central analgesic drugs, and the secondary drugs are sedative and anti-anxiety drugs, antidepressants, immunomodulators and gastrointestinal function regulating drugs. 2.Early regional nerve block anti-inflammatory and analgesic Subcutaneous infiltration injection of nerve block anti-inflammatory and analgesic drugs as early as possible during the acute phase of herpes, and intradermal injection of nerve block anti-inflammatory and analgesic and immunomodulatory agents after the lesion is healed. Paravertebral nerve root block and sympathetic nerve block should be performed at the right time. Injection of therapeutic drugs around the nerve roots in the paravertebral foramen of the spine or the use of corresponding sympathetic nerve segment block can both effectively provide clinical analgesia and avoid the systemic risks of intravertebral puncture injections, especially repeated operations. 4.Topical drugs and phototherapy Some patients use topical osmotic anti-inflammatory analgesics, local anesthetics and phototherapy in between regional injections. 5.The use of intradural spinal cord electrical stimulation analgesia (SCS) is actively recommended SCS is an advanced method promoted worldwide, but it has not been used much in China due to the high cost. 6.Implement nerve destruction techniques prudently Try a variety of neuromodulation treatments If the patient’s pain cannot be effectively relieved, implement radiofrequency ablation of nerve roots and chemical destruction techniques according to the onset site and the patient’s needs to block the nerve conduction function for a long time and improve the overall quality of life. 7, pay attention to psychological counseling and treatment Long-term severe pain patients are accompanied by varying degrees of psychological disorders, such as anxiety, tension, depression, abnormal personality traits and even suicidal tendencies, if drug therapy or nerve block alone has no significant effect on this type of pain, it must be supplemented with the corresponding effective psychological treatment. Our psychological counseling includes the improvement of the patient’s environment and living conditions, the role of the language of the surrounding people, special arrangements and specialized psychotherapeutic techniques implemented by the physician.