When you wake up with pain in your stomach, you should first consider different diseases depending on the location of the pain. If the pain is in the upper abdomen or around the navel, it may be caused by gastric ulcers or duodenal ulcers, commonly gastric ulcers and duodenal ulcers with high gastric acidity. At night, after the digestion of food in the gastrointestinal tract, the stomach will secrete gastric acid, if it is an ulcer of the gastric sinus or duodenal bulb, under the action of gastric acid there will be obvious pain, and the patient will sometimes be woken up by the pain, you can carry out gastroscopy for clarification. If ulcerative lesions of the gastric sinus and duodenum can be detected, oral medication is needed for treatment, such as oral omeprazole, clarithromycin, amoxicillin, and gastroscopy should be performed after one month. If there is pain in the right lower abdomen, it may be caused by appendicitis, and it is necessary to check the blood routine for white blood cells, as well as to perform an ultrasound examination of the appendix. If there is swelling of the appendix, oozing around the appendix, or even fecal impaction in the appendiceal cavity, it can be clarified, and laparoscopic appendectomy is recommended after clarification.