The blisters on the baby’s mouth may be herpes simplex or impetigo, patients can take oral or topical appropriate drugs, as follows: 1, herpes simplex: patients can take oral vasiclovir hydrochloride tablets, topical acyclovir ointment, but also to take immunomodulators, such as mushroom mushroom polysaccharide tablets or pidomod oral solution. The rash of this disease is characterized by clustered distribution of blisters, accompanied by burning and tingling; 2. Impetigo: patients can take oral treatment with appropriate antibiotics, such as azithromycin, roxithromycin, cephradine, etc., and they can use topical mupirocin ointment or fusidic acid ointment and clindamycin phosphate gel. Patients should avoid excessive scratching or scalding with saline, alcohol or vinegar. This disease is mainly caused by bacterial infection, and impetigo can be combined with erythema and rupture.