The causes of a big belly are physiological and pathological, and the pathological causes include Cushing’s syndrome and liver disease. 1. Physiological factors: abdominal fat is easier to accumulate, with the increase in age, the accumulation of fat in the abdomen more and more. Even in the normal weight range, if you do not pay attention to exercise, there will be a body not fat stomach. Actively participate in exercise, the symptoms can be gradually reduced. 2. Pathological factors: due to individual differences, need to choose the right drugs under the guidance of the doctor. Cushing’s syndrome is caused by adrenal secretion of hormones and leads to centripetal obesity. It can be treated with dopamine inhibitor bromocriptine, adrenocorticotropic hormone inhibitor ketoconazole, etc. In severe cases, surgery can be used to remove the pathogenic factors. Cirrhosis can lead to portal hypertension, gastrointestinal stasis and thus abdominal distension, which can be treated by transjugular intrahepatic portosystemic shunt. Patients should go to the hospital immediately when they experience discomfort.