Finger (toe) bone infarction is one of the symptoms of sickle cell anemia (crescentcellanaemia, sickle-cellanemia), which is a hereditary blood disorder and can also become a pure-hybrid sickle cell disease with clinical manifestations of varying degrees of hemolytic anemia and mild jaundice. Vascular occlusive crisis is its prominent manifestation, often with severe pain at the trunk and extremities, including visceral, bone, joint and muscle pain, especially metacarpal, epiphyseal and phalangeal (toe) infarcts are common, with infection, dehydration, hypoxia and acidosis as its triggers. Infection, dehydration, hypoxia and acidosis are the causes. Visceral and cerebrovascular infarcts show corresponding signs and symptoms. Examination of finger (toe) bone infarction caused by sickle cell anemia: 1. Peripheral blood Hemoglobin is 50-100 g/L, further reduced in critical conditions. The reticulocyte count is often above 10%. Erythrocyte size is uneven, with increased multicolored, basophilic dot-colored cells, and nucleated erythrocytes, target-shaped erythrocytes, heterogeneous erythrocytes, and Howell-Jolly vesicles are seen. Sickle cells are uncommon, but if found, they can be useful for diagnosis. The presence of sickle cells is usually checked by the “sickle test”. There is a significant decrease in the osmotic fragility of the red blood cells. White blood cell and platelet counts are usually normal. Bone marrow picture shows significant hyperplasia of the red lineage, but hypoplasia in aplastic crisis and megaloblastic transformation in megaloblastic crisis. 3.Serum bilirubin is mildly to moderately increased, and it is significantly increased in hemolytic crisis. Although the hemolysis in this disease is mainly extravascular hemolysis, there is also intravascular hemolysis. 4.Plasma-bound hemoglobin is decreased, and plasma free hemoglobin may be increased. 5.Red cell half-life measurement shows a significant shortening of red cell survival time to 5-15 days [normal is (28±5) days]. 6.Hemoglobin electrophoresis shows that HbS accounts for more than 80%, HbF increases to 2%-15%, HbA2 is normal, and HbA is absent. Choose to do ECG, X-ray, CT, MRI, ultrasound, biochemistry and other tests according to the condition, clinical manifestations, symptoms and signs.