Merrill’s main ingredient is ibuprofen and Tylenol’s main ingredient is acetaminophen, both of which have their own advantages and disadvantages. Ibuprofen and acetaminophen are not only recommended by the World Health Organization as antipyretic and analgesic drugs, but also the two drugs with better clinical application, not only have good fever-reducing effect but also have fewer side effects, which can be tolerated by both adults and children. The advantage of ibuprofen is smooth and long-lasting fever reduction, the average time of controlled fever reduction is about 6-8 hours, especially for high fever above 39 ℃ fever reduction effect is better. This product has mild gastrointestinal reactions, some patients may have a burning sensation in the stomach, nausea, vomiting and other symptoms, and occasionally rash, headache, tinnitus, elevated aminotransferases affecting coagulation function and other manifestations, there are also reports of gastrointestinal bleeding and aggravation of ulcers, so be careful to monitor the use of the process. Acetaminophen is equivalent to ibuprofen with fewer side effects, is better tolerated, and is rapidly absorbed, producing antipyretic effects within 30 minutes after oral administration. However, its fever-reducing time is relatively short, averaging only about 2-4 hours, and there is a risk of liver function impairment with large amounts of application. Patients can choose to apply these two drugs or take them alternately according to their own conditions.