According to the news of the State Administration of Traditional Chinese Medicine, on March 18, the first batch of national medical team of Chinese medicine (Chinese Academy of Traditional Chinese Medicine), led by Huang Luqi, academician of the Chinese Academy of Engineering and president of the Chinese Academy of Traditional Chinese Medicine, who assisted in the fight against epidemics in Hubei Province, was notified by the State Drug Administration that the clinical trial approval was granted for the Dampness Defeating Poison Granules developed by the team. The clinical approval of the granules is the first clinical approval of Chinese medicine for the treatment of the new crown pneumonia approved by the State Drug Administration. It is the result of the combination of the theory and clinical practice of TCM for this epidemic. According to the Chinese Academy of Traditional Chinese Medicine, the new drug development of Dampness Defeating Poison Granules has gone through four stages, namely prescription determination, efficacy confirmation, new drug development and registration declaration. The medical team of the Chinese Academy of Traditional Chinese Medicine was engaged in the treatment of patients with severe New Crown Pneumonia in Wuhan Jinyintan Hospital, and on the basis of the national clinical treatment plan, “while saving and treating, summarizing”, carried out the exploration of the disease law and effective treatment plan with clinical saving as the core, and further optimized to obtain – -The formula was optimized and obtained. During the treatment of Wuhan Xinguan pneumonia patients, this formula played an active role in fighting the virus, eliminating inflammation and improving immunity. The formula has been approved by the members of the national TCM medical treatment expert group, including academician Tong Xiaolin, Liu Qingquan and Zhang Zhongde, as well as academician Wang Yongyan, national medical master Chao Enxiang, national medical master Xue Boshou, and other expert advisors, and experts such as Liu Jinyuan and Zhang Hongchun, etc. Academician Wang Yongyan also made a formula explanation for the formula, and it was included in the sixth and seventh editions of the “New Coronavirus Pneumonia Treatment Protocol It was included in the sixth and seventh editions of the “New Coronavirus Pneumonia Treatment Protocol” and applied in the front line. Around the formula for defeating dampness and toxin, the front carried out clinical efficacy observation and case accumulation of heavy, light and common types in Jinyintan Hospital, East-West Lake Fangcai Hospital and General Street Community Health Center respectively. At this stage, the front and the back side rubbed together to form a seamless working mode of data transmission, collation, processing and analysis, which promoted the transformation from experience to data and provided sufficient evidence of human experience for new drug declaration. In the early stage of clinical treatment, the latter also made preparations for new drug development. After identifying the formula for defeating dampness and toxins, the contingency task of the Chinese Medicine Prevention and Control Technology System for Influenza of the Chinese Academy of Traditional Chinese Medicine was initiated. Relying on Xiyuan Hospital to complete the research and development of hospital preparations to form the Huayu defeat toxin granules, and on February 20, it obtained the record of Beijing Municipal Bureau of Drug Administration. Among them, in accordance with the requirements of new drug development, the completion of the formulation process, quality standards and pilot production and other pharmacological research tasks. The GLP Center of the Institute of Chinese Medicine, completed the acute toxicity experiments and formed the declaration materials. During the period, the Institute of Laboratory Animal Research of the Chinese Academy of Medical Sciences evaluated the antiviral effect of the Huayu Deficiency Granules using the new coronavirus animal model. In accordance with the special approval procedure of the State Drug Administration, the project team submitted the new drug registration application to the National Drug Examination Center on March 11; on March 18, the clinical trial approval of the new drug was obtained, which is the first approved clinical trial approval of a new drug for the treatment of neo-crown pneumonia. In the next step, the project team will actively promote the pharmacological and clinical trial work in accordance with the requirements of the approval. According to the preliminary research through the autopsy and pathology of New Coronavirus pneumonia, although the infection of New Coronavirus is mainly manifested as viral pneumonia, it can in fact cause damage to several important organs and immune system of human body. In this regard, TCM takes a holistic approach and considers the human body as a whole when developing tactics to deal with Neoplastic pneumonia. The etiology of Neoplastic pneumonia in TCM is toxic, damp, cold, heat, dryness, stasis, and deficiency. Aiming at the mechanism of action of the virus, it transforms dampness and eliminates filth, promotes the lung and internal organs, and activates the blood to detoxify the toxin. It is composed of fourteen herbs, which are cut from several classical prescriptions. If we consider the fight against the “new crown virus” as a ball game, tactically, specifically, in the front field, targeting the lung, where the virus mainly infects, some of the drugs in Mao Xing Gan Shi Gan Tang and Xuan Bai Cheng Qi Tang are mainly selected to promote the lung to clear the drainage and disperse the upper jiao; in the middle field, the drugs in Da Yuan Drink and Huo Xiang Zheng Qi San, which can resolve dampness and harmonize the stomach, are selected to mediate the middle jiao. In the back field, the main task is to invigorate the blood and detoxify the toxin, so the drugs from Tao Ren Cheng Qi Tang and Scape Dazhong Da Zao Di Lung Tang are mainly selected to reach the lower jiao; in response to the damage to the immune system caused by the new coronavirus as reflected in the clinical autopsy, the formula for resolving dampness and defeating toxin is also targeted to strengthen the defensive force and enhance the body’s resistance, so Huang Qi Chi Feng Tang and Yu Ping Feng San are selected to tonify the qi and support the righteousness and regulate the qi and blood. Therefore, Huang Qi Chi Feng Tang and Yu Ping Feng San, which play a role in nourishing Qi and supporting correctness and regulating Qi and blood, were selected. From the clinical point of view, through the observation of the effect of using the formula in 75 severe cases, it was found that there was a significant difference in the conversion of nucleic acid and the improvement of symptoms with the formula of defeating dampness and toxicity. In addition, a randomized control of 452 cases in Fangzhai Hospital showed significant differences in the conversion of nucleic acid and symptoms. In addition 124 cases were done at the General Road Health Center, which also showed significant differences. This was confirmed by the scientific evaluation carried out by the Chinese Academy of Traditional Chinese Medicine and the Institute of Medical Laboratory Animals of the Chinese Academy of Medical Sciences, where coronaviruses were used to infect experimental mice, and the improvement of their lung inflammation. The dissection revealed a tragic attack of the virus on the immune system. The virus attacked the immune system with a severe drop in lymphocytes, even with AIDS-like changes, and with massive damage and depletion of immune cells. A bioinformatics study by the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences found that 10 of the 14 herbs constituting the formula for defeating dampness and toxicity have binding power to the Mpro and Spike proteins of the virus, and the remaining 4 herbs are mainly reflected in their effects on immunity, inflammation and related signaling pathways. Content source: People’s Daily Online