There are many reasons why it is difficult to get pregnant and it is not only the woman’s problem, but also the man’s factors that can affect the probability of pregnancy. For women, the most common factors are tubal blockage, hydrocele, and polycystic ovary syndrome, which can cause immature eggs and irregular menstruation. In addition, if a woman has mycoplasma infection, thyroid abnormalities and other endocrine disorders, the probability of pregnancy is also reduced. In addition, antiphospholipid antibody syndrome, anti-endometrial antibodies, and positive anti-sperm antibodies can also have an impact on pregnancy. Men with congenital sperm malformations, poor sperm quality, azoospermia, oligospermia, etc. can also affect pregnancy.