Irbesartan should not be taken by those who are allergic to Irbesartan, pregnant or lactating women, diabetic or those with moderate or severe renal impairment. Irbesartan is a class of drugs for the treatment of type 2 diabetic nephropathy with primary hypertension or combined hypertension, which can selectively block angiotensin-II receptors, inhibit vasoconstriction and aldosterone release, to achieve the effect of lowering blood pressure. Adverse reactions such as dizziness, nausea and vomiting may occur after use. In terms of contraindications to the use of Irbesartan, those who are allergic to Irbesartan, pregnant women in the 4th to 9th month of pregnancy, nursing women, patients with diabetes or moderate-to-severe impaired renal function can not be used in conjunction with Aliskiren, and patients with diabetic nephropathy can not be used in conjunction with angiotensin-converting enzyme inhibitors (ACEIs). Please consult your physician for specific medication precautions, and seek medical attention promptly if serious adverse reactions occur or if symptoms are not alleviated after use.