There are many reasons for blisters on the legs, there may be large and small blisters, there may be only one blister alone, or there may be a blister, the specific reason should be based on the shape of the blister and other accompanying symptoms to comprehensive judgment. 1, allergic reaction: blisters of small size accompanied by severe itching, may be caused by allergies eczema or contact dermatitis, you need to first away from allergens, avoid eating foods that cause allergies. You can also take oral anti-allergy medication and topical creams under the guidance of a doctor to relieve the discomfort of the skin; 2. Herpetic disease: Herpetic disease occurs in middle-aged and elderly people and is an immune disease. If the patient is elderly and suffers from hypertension, diabetes, cardiovascular and cerebrovascular diseases, it may be considered a herpetic disease, and needs to go to a regular hospital to improve the examination and treatment under the diagnosis of the doctor; 3, herpes zoster: if the blisters are accompanied by obvious pain and itching, and the blisters are arranged in a band, it needs to be considered possible herpes zoster, after the doctor clearly diagnosed can use antiviral drugs Such as acyclovir, etc. for treatment; 4, leg variant vasculitis: may also be caused by leg variant vasculitis. When this disease strikes, small blisters of varying sizes will also appear on the local skin of the patient’s legs. Regardless of which cause of the blistering, patients need to maintain a relaxed state of mind, avoid excessive mental tension, actively investigate the cause and cooperate with treatment in order to improve the symptoms.