Patients with reflux esophagitis with depression need to be treated for different diseases, mainly general treatment, medication, psychotherapy, physical therapy and so on. 1. Reflux esophagitis: elevate the head of the bed 15-20 cm when sleeping, 2-3 hours before bedtime should not eat, obese patients to reduce body weight; in addition to the use of omeprazole, cimetidine to inhibit gastric acid secretion as prescribed by the doctor, doxepinolone, moxapride and other drugs to promote gastrointestinal dynamics; surgical treatment is based on anti-reflux surgery, the most common is laparoscopic fundoplication. 2. Depression: antidepressant drugs such as fluoxetine, paroxetine, duloxetine, etc. can be considered as prescribed by doctors; psychotherapy, including supportive psychotherapy, cognitive behavioral therapy, etc., can also be carried out; physical therapy including repeated transcranial magnetic stimulation, etc.. Patients who present with reflux esophagitis combined with depression should actively cooperate with doctors for treatment.