Positive anti-mitochondrial M2 antibody is generally indicative of primary biliary cirrhosis, which requires timely consultation, liver function, liver puncture and other tests for clarification, and timely treatment upon diagnosis. Primary biliary cirrhosis has no obvious symptoms, but may have symptoms such as skin itching, fatigue, jaundice and steatorrhea, etc. Anti-mitochondrial antibody is important for the diagnosis of primary biliary cirrhosis, among which anti-mitochondrial M2 antibody has the highest specificity and sensitivity. Prompt treatment is needed after diagnosis. It is recommended that patients with positive antimitochondrial M2 antibodies should go to the hospital in time to avoid delaying their condition.