Positive antinuclear antibodies are usually indicative of autoimmune diseases such as systemic lupus erythematosus, mixed connective tissue disease, etc., which require further relevant examinations and medication or other treatments according to the cause of the disease. Antinuclear antibody is an autoantibody closely related to the development of autoimmune diseases. Positive results are associated with autoimmune diseases such as systemic lupus erythematosus, mixed connective tissue disease, dry syndrome, systemic sclerosis etc., which need to be further improved with autoantibody profiles, blood sedimentation, CRP, ultrasound, CT and other auxiliary tests to make a clear diagnosis. After the diagnosis is clear, appropriate treatment should be carried out according to the specific type of disease. For example, the treatment of SLE is mainly based on non-steroidal anti-inflammatory drugs such as acetaminophen, anti-malarial drugs such as hydroxychloroquine, immunosuppressants such as methotrexate, glucocorticosteroids such as prednisone, etc., and plasmapheresis or immunoabsorption therapy is feasible when necessary. Test results need to be interpreted by a professional physician, and it is recommended that patients with positive antinuclear antibodies go to the rheumatology and immunology departments of regular hospitals for detailed consultation.