Polycystic ovary syndrome (PCOS) is a polygenic related disorder that manifests itself in a complex genetic pattern and is currently difficult to cure. Due to the high degree of heterogeneity of clinical manifestations in PCOS patients with different ages and treatment needs, clinical management is based on individualized symptomatic treatment measures according to the patients’ complaints, treatment needs, and metabolic changes, which have been achieved to alleviate the clinical symptoms, satisfy the need for reproduction, maintain health, and improve the quality of life. The main treatment principle of polycystic ovary syndrome is to adjust the menstrual cycle and try to prevent the development of long-term complications. Whether patients with polycystic ovary syndrome have fertility requirements or not, they should first undergo lifestyle modification, mainly for controlling diet, exercise and quitting smoking and drinking. In obese patients, reducing body weight by 5% or more through low-calorie diets and energy-intensive exercise may change or reduce symptoms such as menstrual disorders, hirsuteness, acne, etc., and may be conducive to the treatment of infertility. Reducing body weight to the normal range improves insulin resistance and prevents the long-term development of the adverse consequences of polycystic ovary syndrome, such as metabolic syndromes of diabetes mellitus, hypertension, hyperlipidemia, and cardiovascular disease. Improving insulin resistance, correcting metabolic abnormalities such as hyperandrogenemia and dyslipidemia, correctly and effectively adjusting the menstrual cycle, and standardizing the management of endometrial hyperplasia on the basis of weight control and lifestyle modification are the key strategies for preventing the long-term complications of polycystic ovary syndrome. After adjusting the menstrual cycle, obesity and insulin resistance treatment, some patients can resume ovulation or successfully conceive, but many patients still can not ovulate spontaneously, and need to be treated with ovulation stimulation. In recent years, for patients with polycystic ovary syndrome who have the requirement of reproduction and combined with other indications of in vitro fertilization, in vitro fertilization-embryo transplantation is also one of the effective therapeutic options.