Taking nifedipine extended-release tablets can be replaced with medications such as hydrochlorothiazide, metoprolol, captopril, and irbesartan, depending on the situation. Nifedipine extended-release tablets are calcium channel blockers, which can reduce the entry of extracellular calcium ions into vascular smooth muscle cells, attenuate excitation and reduce vasoconstriction. If oral nifedipine extended-release tablets do not work well or if adverse reactions such as increased heart rate, facial flushing, and lower extremity edema occur, the medication can be changed. Common antihypertensive drugs also include thiazide diuretics represented by hydrochlorothiazide, but can affect uric acid elevation and should not be used by patients with gout. They can be replaced with beta receptor antagonists including metoprolol, but can slow the heart rate and should not be used by people with acute heart failure, sick sinus node syndrome, or atrioventricular block. It can also be replaced with angiotensin-converting enzyme inhibitors including captopril, adverse effects are mainly irritating dry cough and angioedema, it should not be used in patients with hyperkalemia, renal artery stenosis, and should be used with caution when creatinine is higher than 3mg/dl. Angiotensin II receptor antagonists can also be chosen, commonly used, including Irbesartan, etc., generally does not cause irritating dry cough, the use of contraindications and angiotensin-converting enzyme inhibitors are the same. Eating nifedipine extended-release tablets can be replaced with a variety of drugs, but there are strict indications or contraindications, it is recommended to use under the guidance of a medical professional.