There are many reasons for multiple bone destruction, such as bone tumor, bone tuberculosis, osteomyelitis, osteoporosis, etc. The treatment needs to be given according to the cause of the disease, such as general treatment, drug treatment and surgery. 1. Bone tumor: there are benign and malignant bone tumors. For benign bone tumors, local scraping and bone grafting or resection is needed in clinic, which can be cured after surgery. If it is malignant tumor, it needs to be given surgical treatment according to the specific condition, such as amputation, etc. After surgery, it also needs to be given radiotherapy, chemotherapy and other auxiliary treatments, and bone metastases need to be treated for the primary disease. 2. Bone tuberculosis: belongs to the infection of bone tissue by tuberculosis bacillus, which can cause multiple bone destruction. Most of them need to be treated with drugs, such as rifampicin, isoniazid and other anti-tuberculosis drugs, and surgical treatment can be given when necessary, such as lesion removal surgery, abscess incision and drainage surgery. 3. Osteomyelitis: acute and chronic infection of bone tissue by bacteria, so antibacterial drugs such as cephalosporins and levofloxacin are needed for treatment. If the disease is serious and simple conservative treatment is ineffective, surgical treatment can be considered, such as lesion excision. 4. Osteoporosis: mainly low bone mass, destruction of bone tissue, usually need to strengthen nutrition, eat more calcium-rich food, appropriate exercise, can take calcium carbonate and other drugs to supplement calcium, take vitamin D can increase intestinal absorption of calcium, alendronate sodium and other can increase bone density. It is recommended that patients go to the hospital, improve the auxiliary examination, in order to clarify the condition, the drugs need to be used under the guidance of a professional physician.