Cracks in the center of the tongue can be caused by trauma, May-Rowe syndrome, vitamin B₂ deficiency and other conditions. 1. Trauma: usually after the tongue is damaged by sharp objects, the cracks in the middle of the tongue often appear after inducing trauma. The patient will also have localized pain and other symptoms. 2. Mero syndrome: the cause of the disease is still unclear, and it is mostly considered to be related to immune function disorders, infections, heredity, allergic reactions and other factors. Patients often have recurrent facial paralysis, recurrent lip and facial swelling, fissured tongue and other symptoms, which can also be manifested as cracks in the middle of the tongue. And some patients may also be accompanied by headache, dizziness, abnormal sense of smell and so on. 3. Vitamin B₂ deficiency: usually due to insufficient intake of riboflavin, absorption disorders, and also related to drugs, metals, hormonal disorders and other factors. It can be manifested as ulceration of the corners of the mouth, scrotal dermatitis, seborrheic dermatitis, conjunctival congestion, etc., and can be accompanied by tearing, photophobia, etc., and some patients may also have fissured tongue, which can be manifested as cracks in the middle of the tongue. It is recommended that when the phenomenon of cracks in the middle of the tongue occurs, the patient should make a clear diagnosis in time and follow the doctor’s instructions to treat it actively.