Spots on both sides of the eyes may be caused by chloasma, brown and blue moles on the cheekbones, and so on. And darkness at the corners of the mouth may be caused by hyperpigmentation, drug factors, lung diseases and so on. 1. Causes of spots on both sides of eyes (1) Melasma: Melasma may be caused by ultraviolet irradiation, heredity, change of sex hormone level in the body and other factors. The patient’s face will have light brown or dark brown spots, so the patient’s eyes on both sides of the corners of the eyes will have the manifestation of long spots. (2) Zygomatic nevus of brownish blue: Zygomatic nevus of brownish blue will appear symmetrically distributed black and gray spots, and the local lesions will be fused into hyperpigmented spots. 2. Causes of darkening at the corners of the mouth (1) Hyperpigmentation: If the patient’s mouth area appears keratitis, herpes simplex, fixed drug rash, allergic inflammation and other diseases. Generally after the inflammation subsides, the local pigmentation will appear, and thus the patient will have the symptom of darkening of the corners of the mouth. (2) drug factors: if the patient is often coated with glucocorticoid ointment in the corner of the mouth, it will also make the local pigmentation, so the patient will have the manifestation of darkening of the corners of the mouth. (3) Lung diseases: patients with bronchial dilatation, emphysema, chronic obstructive pulmonary emphysema and other lung diseases will lead to hypoxia, and patients will also have the symptom of darkening at the corners of the mouth. It is recommended that patients appear on both sides of the corner of the eye spots or the corners of the mouth black performance need to consult a doctor in a timely manner, need to choose the appropriate measures under the guidance of the doctor treatment.