Two years after rectal cancer surgery, nodule on liver may disappear with chemotherapy, depending on the nature of the nodule and the cause of the nodule. If there is nodule on liver two years after rectal cancer surgery, it may be benign nodule on liver, if it does not cause obvious discomfort, most of the symptoms do not need to take special treatment, if it presses on local tissues, it can be treated by surgery, and chemotherapy is usually not carried out. If there are malignant nodules on the liver, it may be the phenomenon of recurrence and metastasis of rectal cancer after surgery, chemotherapy can be taken which is generally more sensitive to chemotherapy, and it can shrink the nodules, or even make the nodules disappeared, but relatively speaking, it is unlikely to disappear completely. If there are nodules on the liver two years after rectal cancer surgery, you need to actively cooperate with doctor to take examination and targeted treatment after clear diagnosis to avoid aggravation of the condition.