Primary care 1.Observe whether the intravenous infusion of chemotherapeutic drugs is smooth and whether there is any extravasation at the infusion site. 2.Concentration: observe whether the patient is unconscious, snoring and other signs 3.Skin and mucous membrane: observe whether the patient’s skin has bleeding spots and color changes; observe whether the patient’s oral mucous membrane is broken; observe the location and degree of limb edema. 4. Digestive system: Observe the degree of nausea and vomiting, and the nature and amount of vomit; observe whether there is occult blood in the stool and the character of stool. 5.Observe the patient’s body temperature, respiration, heart rate and the dynamic change of blood pressure. 6.Monitoring laboratory indicators: routine blood, liver and kidney function, blood glucose, fecal occult blood test. For patients with myelosuppression, do a good job of protective isolation. 7.Strictly record the amount of in and out, and give light diet during chemotherapy. Secondary care 1, observe whether the intravenous infusion of chemotherapy drugs is smooth and whether there is extravasation at the infusion site, observe the infusion of chemotherapy drugs and local skin condition, and eliminate extravasation of chemotherapy drugs. 2.Monitor the changes of vital signs, understand the patient’s feelings, effective communication, relieve the patient’s psychological pressure. 3.Know the clinical manifestations of the disease, so as to facilitate self-observation. 4.Strengthen the intake of nutrients. Tertiary care 1.Dietary guidance: strengthen the intake of nutrients to ensure adequate nutrition. 2.Ensure the time and quality of rest, appropriate activities, avoid overwork. 3.Re-check the blood picture regularly and contact the doctor in time if there is any abnormality. 4.According to the prescribed time for rechecking. Discharge guidance 1, dietary guidance: into the high protein, high vitamin light food, to ensure adequate nutrition. 2.Continue to carry out the functional exercise of the affected limbs. 3, the next hospitalization fasting water. 4.Take chemotherapeutic adjuvant drugs on time. 5.According to the doctor’s instructions, review the blood picture regularly, and contact the doctor or nurse in time if there is any abnormality. 6.Regular follow-up.