Cranial bone is an important bone in our head, it is the barrier between our brain and the outside world, protecting the normal operation of the brain tissue. Cranial bone may be defective due to many reasons, such as accidental fall from a height, being hit by a heavy object that can easily cause brain damage, or because of the lesion of the skull itself that requires bone flap surgery, thus causing the defect of the skull. The cranial defect will cause the patient to have a great psychological obstacle in the long term, because the brain collapse or bulge will make the patient feel different from the normal people, resulting in inferiority complex and lack of self-confidence, which will affect the patient’s life and work to a great extent. Therefore, patients with large skull defects should undergo skull repair surgery as soon as possible within three months after surgery. Of course, the material used to repair the skull is very important, some repair materials can also cause side effects after the repair, currently the most widely used titanium mesh, some patients will have rejection reactions or other side effects after using it, so patients should also carefully choose the repair hospital and materials. At present, we use a new type of material to repair the skull for patients, polyether ether ketone material, which is commonly known as peek material is the most ideal repair material recognized by many experts at present, since its use, many skull repair patients have undergone repair surgery through peek material, and after long-term follow-up, it is found that the basic recovery after surgery is very good.