Whether creatinine 139 μmol/L is serious depends mainly on the cause of the elevation. If it is caused by physiological reasons or acute kidney injury, creatinine may return to normal after removing the influencing factors, and it is usually not serious at this time. If it is caused by chronic kidney disease, with the progress of the disease, there will be a progressive increase in blood creatinine, and may develop into uremia, which is relatively serious. Normal serum creatinine ranges from 53 to 106 μmoI/L in men and from 44 to 97 μmoI/L in women. Some patients with elevated creatinine may be due to their own high muscle content, or usually eat more meat and exercise caused by more, if the routine urine and urinary system ultrasound and other related examinations do not see abnormalities, clear kidney without obvious diseases, such cases are usually not serious. If the patient due to various reasons for acute kidney injury creatinine elevation, after correcting reversible causes, creatinine may return to normal, this is usually not serious; if chronic kidney disease caused by creatinine elevation, with the progress of the disease, may develop into uremia, this is relatively more serious. If patients find elevated creatinine, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.