When lumbar vertebrae 4-5 compress the nerves, you need to choose the appropriate treatment according to the cause of the disease, and the common causes include: lumbar disc herniation and lumbar spondylolisthesis. Its treatment usually includes general treatment, physical therapy, medication and surgery. 1. Lumbar disc herniation: when the nerve is pressed, strict bed rest is needed, and regular massage, acupuncture and other physical therapy can also be chosen. If there are pain symptoms, non-steroidal anti-inflammatory drugs, such as ibuprofen, celecoxib, etc., can also be chosen, and dehydrating agents, such as mannitol, can also be used to alleviate nerve edema. When the symptoms are severe, or when conservative treatment is ineffective, surgical treatment needs to be considered. 2. Lumbar spondylolisthesis: It is also necessary to take strict bed rest, reduce the activities on the ground, and also use non-steroidal anti-inflammatory drugs, such as celecoxib, meloxicam, etc., to help reduce the pain, and also use the dehydrating agent, such as mannitol, to relieve the neural edema. Surgery should be considered if symptoms such as recurrent, severe back pain or leg pain occur. The above medications should be used under medical supervision. When lumbar vertebrae 4-5 compresses the nerves, you should seek immediate medical attention and receive regular treatment under the guidance of a doctor, which should not be taken lightly to avoid serious consequences.