Physical activity is an inexpensive, non-invasive means of disease control, and the international recommendation is at least 150 minutes of physical activity per week of moderate intensity exercise, or 60-75 minutes of higher intensity exercise, which is an established form of physical activity management. Greater weight loss can be achieved. Postmenopausal women may gain unique benefits after exercise training because there is an increase in overall and abdominal fat after menopause, and, as body fat, abdominal fat and weight gain increase the risk of postmenopausal breast cancer, endometrial cancer, colorectal cancer, metabolic syndrome and type 2 diabetes and cardiovascular disease may be affected by postmenopausal obesity, exercise training reduces the risk of postmenopausal breast cancer, in Partly through regular body fat, however, how much intense physical activity performed will affect postmenopausal obesity is not known. The benefits of a series of exercise were established in randomized clinical trials, however, few randomized clinical trials were designed to compare the duration of exercise and, without targeting postmenopausal women who performed more than 250 minutes of exercise per week, a series of comparative studies were conducted at lower intensities and durations of exercise and less than 6 months, included men and less than 50 participants per group, and did not measure obesity, we in study experiment in which 320 postmenopausal women were subjected to 225 minutes of moderate to vigorous aerobic training per week for sedentary postmenopausal women and demonstrated reductions in body weight, body fat, subcutaneous fat, and intra-abdominal fat relative to the control group, with favorable trends in fat loss and exercise duration in exploratory analyses of less than 150.150-225 and more than 225. However, the experiment was not designed to test some response effects in the study, in which we tested whether there was a change in obesity in sedentary postmenopausal women randomized to high-intensity and moderate-intensity exercise prescriptions, with the aim of studying the role of physical activity in weight control and breast cancer prevention guidelines for postmenopausal women. Exercise training was progressively increased over 12, reaching 5 days per week at week 13 with 30 minutes (moderate) or 60 minutes (high) intensity training to reach 65% to 70% of maximal cardiorespiratory reserve, (assessed every 3 months), with supervised and unsupervised training during training, and 3 days per week of supervised training and 2 days per week of unsupervised training at home, from weeks 13 to 52. The type of exercise, exercise duration, exercise continuous heart rate reserve, maximal heart rate, borg index, exercise frequency, exercise duration and heart rate were recorded by the supervisor, patients reported the type of exercise and borg index, and patients requested no change in diet. Aerobic heart rate reserve ranged from 65-75% during the trial. In the first 2 training groups, participants trained one-on-one and were trained by the trainer in the use of exercise equipment, including a running platform, power bicycle, and air walker, and the trainer also provided comprehensive exercise training guidelines and home exercise training and appropriate exercise training modalities. During 12 months of exercise training, sedentary postmenopausal women with a BMI of 22-40 underwent significant reductions in body fat production after exercise training at 300 and 150 min/wk, with significant reductions in BMI, waist-to-hip ratio, waist circumference, subcutaneous fat, and total fat in the high-intensity group, and more pronounced in obese women (BMI >30). There was a 2% reduction in body fat, but no significant change in total fat, however, studies have demonstrated that aerobic exercise requires at least 225 Min/wk to better reduce body fat in postmenopausal women. Adipose tissue is a major immune and metabolic tissue, a major source of inflammatory cytokines, adipokines, and oxidative stress in postmenopausal sex hormones, and may serve as a biomarker for breast cancer risk; therefore, we found that a reduction in total fat may reduce the risk of breast cancer development, possibly also through these mechanisms. Abdominal fat was studied separately as abdominal fat may have different effects from total fat and is also a risk factor for postmenopausal breast, pancreatic and endometrial cancers, however it is not clear that visceral obesity increases the risk of postmenopausal breast cancer, although it has been biologically proposed to be associated with insulin resistance, type 2 diabetes and metabolic syndrome and may be related to mechanisms, as our previous study showed No specific effect of subcutaneous fat, but a significant effect relative to other experiments, other explanations may be age correction, similar exercise intensity and insufficient amount of exercise prescription. The association between physical activity and postmenopausal breast cancer risk is supported by more than 100 epidemiological studies and by strong biological theories that support the association between fat loss as a major factor, and our study shows that exercise training to reduce total and visceral fat is effective in obese women and that for postmenopausal women at least 300 min/wk of exercise training is required to prevent tumors for every 5 unit increase in BMI. A 5 unit increase in BMI is associated with a 33% increase in breast cancer incidence in postmenopausal women at estrogen receptors and progesterone receptors, a 4.6 and 6.9% reduction in risk of breast cancer incidence and a 2.3% increase in benefit after moderate and higher aerobic exercise, and in obese women the increase in benefit may be even greater, reaching 5.5% and a 4.8 and 10.3 reduction in risk, studies suggest that some of our results may be reduced by moderate adherence, subcutaneous fat may have a different response curve than total fat and may have different effects depending on BMI and age, studies detecting different exercise prescriptions, individualized fat loss, trends in exercise compensation, and predictions of exercise adherence may increase the effect of exercise prescription.