There is no basis for the claim that Guiding Chi San is the best treatment for what disease, Guiding Chi San is mainly used for treating the cardiac meridian fire-heat syndrome. It is a traditional Chinese medicine formula that has the effect of clearing the heart, inducing diuresis and nourishing Yin. Therefore, it is used for the treatment of heart meridian fire-heat syndrome, which can be seen in the symptoms of heart and chest irritation and heat (irritability and sultriness) and thirst and face redness as well as mouth and tongue sores. It is also commonly used in the treatment of stomatitis and thrush, which are characterized by heat in the Heart meridian. In this formula, Radix et Rhizoma Shengdi cools the Blood and nourishes Yin in order to control Heart fire, while Mutong clears Heart fire upwards and directs heat in the small intestine downwards. Bamboo leaf clears the Heart and removes vexation (removes vexation and heat in the heart), and is the subject’s medicine. Sheng Gan Cao Ting can harmonize all medicines (harmonize the medicinal properties of different Chinese medicines), and is the adjuvant in the formula. The adverse effects and contraindications of Guiding Chi San are not yet clear. It should be used with caution for those with weak spleen and stomach. When using medication, you need to be guided by a traditional Chinese medicine practitioner to use the medication, do not use the medication arbitrarily, so as to avoid adverse consequences.