The pain in the middle of the two chests of men may be caused by esophagitis, costochondritis, pleurisy and other diseases. 1. Esophagitis: Esophagitis may be caused by factors such as weakening of anti-reflux barrier, decrease of esophageal contouring ability, and decrease of barrier effect of esophageal mucosa. Patients will have chest pain, dysphagia, painful swallowing, acid reflux and other symptoms, which manifest as pain in the middle of both chests. 2. Costal chondritis: Costal chondritis may be caused by pathogen infection, chronic strain, trauma and other factors. Patients may have pain in the anterior part of the chest, and the symptoms of pain will be aggravated when coughing and deep breathing, manifesting as pain in the middle of both chests. 3. Pleurisy: pleurisy may be caused by surgery, pneumonia, malignant tumor, infection and other factors. Patients may have chest pain, chest tightness, the nature of the pain is mostly stabbing and pulling pain, manifested as pain in the middle of the chest. There are many causes of chest pain in men, and it is recommended that patients go to regular hospitals and undergo relevant examinations to identify the cause of the disease. Once the diagnosis is confirmed, you need to actively cooperate with the doctor to take relevant treatment measures.