The need for long-term medication for interstitial cystitis is related to the symptoms, the effectiveness of treatment, and the treatment modality, and cannot be generalized. Interstitial cystitis is a group of syndromes with frequent urination, urinary urgency, pain in the bladder or pelvis as well as in the perineal area as the main clinical manifestations. The treatment of this disease is mainly drug treatment or surgical treatment. 1. Drug treatment: (1) Intravesical treatment: It mainly includes intravesical instillation of drugs, such as heparin; therapeutic water dilatation of the bladder; intravesical injection of drugs, such as triamcinolone acetonide, etc. This type of treatment usually does not require long-term medication. This type of treatment usually does not require long-term medication. (2) Extravesical treatment: It mainly includes oral antidepressants, such as amitriptyline; immunosuppressants, such as cyclosporine A; and non-steroidal anti-inflammatory drugs for pain relief. If the symptoms are mild, long-term oral medication may not be needed; if the symptoms are severe and the treatment is not effective, long-term medication may be needed. 2. Surgical treatment: mainly includes transurethral resection, bladder enlargement, total bladder resection and so on. After surgical treatment, long-term medication may not be needed. All of the above medications should be used under doctor’s guidance, avoid self-medication. Patients with interstitial cystitis are advised to go to regular hospitals in time for standardized treatment under doctor’s guidance.