High blood sedimentation can be determined by calcitoninogen test, autoantibody test, and tumor marker test. 1. Calcitonin: It can exclude whether there is bacterial infection. If the value is less than 0.05ng/mL, it suggests that there is no infection in the body. If the value is greater than 0.5ng/mL, it suggests that the body may have different degrees of infection. 2. Autoantibody test: It can determine whether there is SLE. If the anti-nucleosome titer, anti-double-stranded DNA antibody titer, and antiphospholipid antibody are significantly elevated, it suggests that SLE may be present. It should also be combined with the patient’s symptoms (e.g. butterfly rash) and imaging tests. 3. Tumor markers: can determine whether there is a malignant tumor in the body, and also need to combine with the patient’s own symptoms and imaging tests. In clinical practice, high blood sedimentation is an important basis for diagnosing most diseases, but it is not an absolute standard. If high blood sedimentation occurs, systematic examination is recommended to identify the cause of the disease.