Genetic metabolic diseases are a large category of conditions, and congenital diseases of the nervous system actually include genetic metabolic diseases, which can lead to neurological symptoms, and the most common ones are actually neurological symptoms, as follows: 1. delayed or regressed development, epileptic cramps, intellectual backwardness, intellectual regression, growth and development backwardness, as well as metabolic acidosis, vomiting, and feeding difficulties; 2. some children have persistent hypoglycemia, and hepatosplenomegaly; 3. relatively short and bad growth. Parents also visit more children because they are short, poorly grown, thin or of low intelligence; 4. Some children have special faces, like some mucopolysaccharidoses, where the children look particularly strange and ugly; 5. Children with low A mucinous edema do not move or eat; 6. Some children are startled and agitated; 7. Special smells, such as phenylketonuria has a rat odor, and maple sugar urine may be the smell of maple sugar. Congenital diabetic ketoacidosis may have the smell of rotten apples. It has a variety of symptoms, and it is a large group of diseases, so if parents find that their children do not eat, feeding difficulties, always vomit, and grow small, always cramps, at the beginning of the very young should come to the hospital, because early may appear biochemical changes; 8, metabolic acidosis can be detected by blood gas examination lactic acid increased or hyperammonemia, these children may be manifested as feeding difficulties Some children with albinism have white hair, white eyebrows and white skin; 10. All parts of the body can be found as long as parents pay close attention to the abnormalities and go to the hospital to ask the doctor what the situation is, so that the child can be treated early and improve his quality of life and prognosis are very helpful.