One year old baby fever 38.5 ℃ not cough and not runny nose can be seen in infectious diseases and non-infectious diseases, the treatment needs to be based on the cause, such as toddler rash can generally be self-cured, the course of the reasonable fever can be, urinary tract infections need to be used according to the type of germs antibiotic treatment, Kawasaki disease need to use immunomodulatory therapy or anti-embolism therapy. 1. Infectious diseases (1) Early childhood acute rash: caused by human herpesvirus infection, commonly seen in this age group of babies, clinical symptoms can appear, most of the general condition is good, no cough, runny nose and other symptoms, often in the fever 3~5 days after the heat out of the rash, usually can be self-cured, the course of the above babies need to be orally administered ibuprofen and other drugs to reduce fever. (2) urinary tract infections: the above phenomenon can occur clinically, urinary tract irritation signs (such as urinary frequency, etc.) is not obvious, improve the urine routine examination can assist in the diagnosis, the treatment requires the use of cefaclor and other drugs for anti-infection, the course of the disease is reasonable to reduce fever. 2. Non-infectious diseases: such as Kawasaki disease, clinical recurrence of fever, not accompanied by respiratory symptoms, most of the rash, hands and feet swelling and other symptoms, some babies can appear cardiac coronary artery dilatation and so on. After the diagnosis is clear, the treatment requires the use of immunomodulatory therapy such as gammaglobulin, aspirin and other anti-thrombotic drug therapy. The above drugs need to be used under the guidance of a physician, and it is recommended to visit a doctor and have the treatment evaluated by a specialist. A one-year-old baby with a fever of 38.5 without a cough or runny nose may also have other causes, it is recommended to go to the hospital, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment. The above drugs should be used under the guidance of a doctor.