Criteria for spontaneous healing of ventricular septal defects include cardiac ultrasound not suggesting a significant left-to-right shunt, and hearing no significant murmur on auscultation. Ventricular septal defect is a relatively common congenital cardiac malformation in clinical practice. It is a condition in which the interventricular septum is underdeveloped during embryonic life, forming an abnormality that produces a left-to-right shunt at the level of the ventricles. Usually, a grade 2-3 systolic murmur can be heard at the left sternal border by auscultation, and left-to-right shunting of the ventricular septum can be detected by cardiac ultrasound. Generally, if the ventricular septal defect is less than 5mm, it may heal on its own, and it is necessary to follow the doctor’s instructions to do regular checkups. If there is no obvious left-to-right shunt on repeat cardiac ultrasound and no obvious murmur is heard on auscultation, it can be considered to have healed spontaneously. Therefore, patients with ventricular septal defects should have regular checkups and consider surgery if necessary. It is recommended that patients seek timely medical treatment and standardize the treatment under the guidance of the doctor.