Focal proliferative IgA nephropathy is generally difficult to cure. Focal proliferative IgA nephropathy may manifest as hematuria, proteinuria, hypertension, impaired renal function, etc., and is prone to recurrent episodes, especially when the patient is overworked, throat infections and skin infections, which may cause the disease to recur or worsen. Focal proliferative IgA nephropathy can be treated with renin-angiotensin-aldosterone receptor antagonist (valsartan, benadryl), hormone (prednisone), immunosuppressant (mertiomacrophenol ester tablets), hydroxychloroquine, etc., which can strictly control blood pressure and proteinuria, and slow down the disease progression. In general, the clinical cure rate is low, and it is necessary to standardize the use of drugs for a long time and monitor the changes of the disease. Focal proliferative IgA nephropathy is harmful, so patients are advised to go to regular hospitals in time for treatment under the guidance of specialists.