Pain inside the nose with headache is commonly caused by pterygopalatine neuralgia, sinusitis, trigeminal neuralgia and other causes. According to the cause and symptoms, we need to choose medication, surgery and other ways to treat the disease and relieve the symptoms. 1. Pterygopalatine neuralgia: under the guidance of the physician to apply phenytoin sodium, carbamazepine and other drugs to treat, can also be used for nasal mucosal anesthesia or pterygopalatine nerve closure, ineffective surgery can be considered (pterygopalatine ganglion block, pterygopalatine ganglion destruction, etc.). 2. Sinusitis: Amoxicillin capsule, metronidazole and other antibacterial drugs can be applied under the guidance of physicians, together with the application of seroquel nasal spray, budesonide nasal spray and so on. If the effect of conservative treatment is not good, endoscopic sinus surgery can be chosen. 3. Trigeminal neuralgia: Carbamazepine, gabapentin and other drugs can be applied under the guidance of the physician, and the serious condition can be treated with gamma knife, closed treatment, microvascular decompression surgery and other methods. Need to go to the hospital, after a clear diagnosis, follow the doctor’s instructions to standardize the use of medication and treatment, they can not just use drugs.