Lung cancer chemotherapy leads to elevated transaminases, on one hand, chemotherapeutic drugs directly damage liver function; on the other hand, it may be reactivation of autologous hepatitis virus.
1. Chemotherapeutic drugs directly damage liver function. During chemotherapy for lung cancer, most of the chemotherapeutic drugs are toxic, and after several cycles of chemotherapy, the side effects of these drugs are more obvious, especially after directly damaging liver cells, which will cause obvious elevation of transaminases and is called pharmacological liver damage.
This condition needs to be treated with liver-protecting drugs, such as silymarin, diammonium glycyrrhizinate enteric capsule, and reduced glutathione. If the chemotherapy regimen is not tolerated, it is necessary to consider changing other chemotherapy drugs.
2. Autologous hepatitis virus reactivation. Some lung cancer patients may be hepatitis B virus carriers or have a history of hepatitis B teratitis, continuous chemotherapy makes the body’s immune function seriously reduced, which may cause reactivation of hepatitis viruses, resulting in liver function damage, and transaminases will be elevated in biochemical examination.
Hepatitis B pentameter test and quantitative test of hepatitis B virus DNA can make a clear diagnosis. Hepatitis B virus-induced liver damage requires antiviral and liver-protecting treatments, and it is recommended to go to the department of infectious diseases for consultation.
If transaminase is elevated after chemotherapy for lung cancer, the examination should be completed as soon as possible to clarify the cause of the disease, and treatment should be carried out in accordance with the doctor’s instruction. Pay attention to rest and ensure sufficient nutrition in daily life.