Medullary sponge kidney stones can be treated with medication, surgery and so on. 1. Medication: mainly treated with potassium citrate and antibiotics. (1) Potassium citrate: the main function of potassium citrate is to reduce the recurrence rate of kidney stones and increase bone density. It needs to be used in a standardized way under the guidance of doctors. (2) Antibiotic treatment: Antibiotics are used to control the continuation of bacterial infection and should be used as early as possible if a urinary tract infection occurs. Before the bacteria of infection are not sure, the doctor carries out empirical treatment, and the drug chooses the third-generation cephalosporin such as ceftriaxone. After the bacteria of infection are clarified, the antibiotics with good therapeutic effect will be chosen according to the type of bacteria. 2. Surgical treatment: If the stone is located below the collecting system, it can be treated according to the extracorporeal shock wave lithotripsy for general stones. If medullary sponge kidney stone is diagnosed, it should be standardized and treated as early as possible under the guidance of doctor.