It is possible, but unlikely, to return to spontaneous breathing after 20 days in a coma. It is recommended that medication and respiratory support be given as prescribed by the doctor. Coma for 20 days without spontaneous breathing indicates that the condition is serious, it is possible to resume spontaneous breathing, but the possibility of resuming spontaneous breathing is relatively small. Comatose patients need to be treated with respiratory stimulants such as Niclosamide and Lobelin, and brain stimulants such as Meclofenoxate and Naloxone under the supervision of a doctor, and also need to be assisted to breathe with the help of a ventilator. The prognosis of comatose patients is recommended to consult a specialized doctor, who will choose appropriate measures to treat the cause of the disease. In addition, the patient should be given nutrients through nasal feeding or parenteral nutrition, and the comatose patient should be turned and patted on the back frequently to prevent bedsores or lung infections.