Catecholamine hypersecretion, also known as pheochromocytoma, originates in the adrenal medulla, sympathetic ganglion, parasympathetic ganglion (paraganglia) or other sites of chromophobic tissue. Due to the paroxysmal or persistent secretion of norepinephrine and epinephrine by the tumor cells, the clinical picture is one of paroxysmal or persistent hypertension, headache, sweating, palpitations and metabolic disorders. If treated early, it can be cured. Ultrasound can detect tumor with diameter >2cm in the adrenal gland, generally the tumor has echogenic enhancement at the edge of the envelope and hypoechoic homogeneity inside, such as hemorrhage, necrosis or cystic changes when the tumor is large and growing fast, However, B-ultrasound cannot show the tumor in some special areas outside the adrenal gland (such as neck, chest, etc.). 2.CT: It is the preferred means of localization. Pheochromocytoma in CT mostly appears as a round-like mass with hemorrhagic area or calcified foci with high density, and the tumor parenchyma is obviously enhanced in enhanced scan, while the necrotic area is not or slightly enhanced. Therefore, it is possible to miss the diagnosis. MRI: T1-weighted image of solid tumor in MRI is similar in intensity to T2-weighted image of liver parenchyma with higher signal. The sensitivity and specificity of MRI in the diagnosis of pheochromocytoma are similar to those of CT, but the advantage is that the three-dimensional imaging is good for observing the anatomical relationship between the tumor and surrounding organs and blood vessels. 4.Isotope 131Ⅰlabeled MIBG scan: MIBG (m-iodobenzylguanidine) is a physiological analogue of NE that can be taken up and stored in pheochromocytoma, and can show the tumor after isotope 131Ⅰlabeling. only 77%-90%. In recent years, the image quality with 123Ⅰ is clearer and can be combined with SPECT tomography for better localization of recurrent or malignant pheochromocytomas and tumors with fibrosis, anatomical variations, and tumors located in rare sites. MIBG imaging is the first choice for the diagnosis of pheochromocytoma when no ectopic tumor is suspected by ultrasound and CT. 5.Intravenous cannulation: CA is measured by segmental blood sampling through intravenous cannulation to clearly localize the diagnosis. It has been gradually replaced by non-invasive tests because of the serious complications that may occur during the operation.