Cerebral infarction with no strength in hands and feet is a kind of limb motor dysfunction caused by cerebral infarction, which mainly refers to distal muscle dysfunction, and limb motor dysfunction includes distal muscle dysfunction and proximal muscle dysfunction. Proximal muscle strength disorder mainly refers to muscle weakness of the upper and lower extremities, and is mainly seen in patients with infarction in the basal ganglia area or radiocoronal area. The symptoms and signs of patients are generally mild, and most patients have no impairment of consciousness, no cerebral edema and no increase in intracranial pressure. The treatment of this disease should mainly be given to anti-platelet aggregation, improve blood circulation, neuroprotection, and also control risk factors. The main drugs to improve blood circulation include sulforaphane, vincristine and chuanxiongzine. Anti-platelet aggregation drugs generally apply aspirin, and clopidogrel can also be used when aspirin is not tolerated. The main neuroprotective drugs are edaravone, cytarabine and cerebroprotein hydrolysate. The main causes of cerebral infarction in the basal ganglia and radiocoronal infarction include hyperlipidemia and hyperglycemia, as well as atherosclerosis. Patients with hyperlipidemia can be treated with oral simvastatin, resulvastatin, or atorvastatin for lipid regulation. Patients with hyperglycemia should be treated with oral metformin or regeneronide to lower glucose, or subcutaneous insulin injection if necessary.